Publications
Eguchi A, Gonzalez AFGS, Torres-Bigio SI, Koleckar K, Birnbaum F, Zhang JZ, Wang VY, Wu JC, Artandi SE, Blau HM. TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs. Proc. Natl. Acad. Sci. USA 120, e2209967120 (2023). PMCID: PMC9963063
Highlighted by Stanford Medicine
Eguchi A*, Birnbaum F*, Pardon G*, Chang ACY, Blau HM. Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates. NPJ Regen Med. 7, 19 (2022). (* equal contribution) PMCID: PMC8933505
Highlighted by Stanford Cardiovascular Institute and Muscular Dystrophy News Today
Chang ACY, Pardon G, Chang ACH, Wu H, Ong SG, Eguchi A, Ancel S, Holbrook C, Ramunas J, Ribeiro AJS, LaGory EL, Wang H, Koleckar K, Giaccia A, Mack DL, Childers MK, Denning C, Day JW, Wu JC, Pruitt BL, Blau HM. Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes. Stem Cell Reports. 16, 2169-2181 (2021). PMCID: PMC8452491
Highlighted by Stanford Cardiovascular Institute
Finn, PB, Bhimsaria D, Ali A, Eguchi A, Ansari AZ, Dervan PB. Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome. PLoS One. 15, e0243905 (2020). PMCID: PMC7755219
Heiderscheit EA, Eguchi A, Spurgat MC, Ansari AZ. Reprogramming cell fate with artificial transcription factors. FEBS Lett. 592, 888-900 (2018). PMCID: PMC5869137
Erwin GS, Grieshop MP, Ali A, Qi J, Lawlor M, Kumar D, Ahmad I, McNally A, Teider N, Worringer K, Sivasankaran R, Syed DN, Eguchi A, Ashraf M, Jeffery J, Xu M, Park PMC, Mukhtar H, Srivastava AK, Faruq M, Bradner JE, Ansari AZ. Synthetic transcription elongation factors license transcription across repressive chromatin. Science. 358, 1617-1622 (2017). PMCID: PMC6037176
Eguchi A, Wleklinski MJ, Spurgat MC, Heiderscheit EA, Kropornicka AS, Vu CK, Bhimsaria D, Swanson SA, Stewart R, Ramanathan P, Kamp TJ, Slukvin I, Thomson JA, Dutton JR, Ansari AZ. Reprogramming cell fate with a genome-scale library of artificial transcription factors. Proc. Natl. Acad. Sci. USA 113, E8257-E8266 (2016). PMCID: PMC5187731
Highlighted in CIRM blog
Erwin GS, Grieshop MP, Bhimsaria D, Eguchi A, Rodriguez-Martinez JA, Ansari AZ. Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin). J. Vis. Exp. 107, e53510 (2016). PMCID: PMC4781686
Erwin GS, Bhimsaria D, Eguchi A, Ansari AZ. Mapping polyamide-DNA interactions in human cells reveals a new design strategy for effective targeting of genomic sites. Angew. Chem. Int. Ed. Engl. 53, 10124-10128 (2014). PMCID: PMC4160732
Eguchi A, Lee GO, Wan F, Erwin GS, Ansari AZ. Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers. Biochem. J. 462, 397-413 (2014). PMCID: PMC4205157
Bishop A, Gooch R, Eguchi A, Jeffrey S, Smallwood L, Anderson J, and Estévez AG. Mitigation of peroxynitrite-mediated nitric oxide (NO) toxicity as a mechanism of induced adaptive NO resistance in the CNS. J. Neurochem. 109, 74-84 (2009). PMCID: PMC2692600
Bishop A, Hobbs KG, Eguchi A, Jeffrey S, Smallwood L, Pennie C, Anderson J, Estévez AG. Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: Implications for multiple sclerosis. J. Neurochem. 109, 93-104 (2009). PMCID: PMC2756289